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It can work. The biggest down side is when the job stops the steppers eventually power down and you gantry will drop. A few of those and you will be causing some damage. Beyond that it is designed with gravity in mind, changing the direction in which gravity acts could cause some issues, the larger the machine the worse they would get a smaller machine wouldn’t have many issues. I think a better approach is just build it on a nice torsion box and put it on a table when you want to use it and shelve it or put it under a table when not in use.
Gut feeling says it wouldn’t like it much.