Wow, I have owned simplify for a long time now and never thought to try and connect directly. I actually don’t know if you can, I’ll have to check in the morning. If it has control software built in than yes it will work, I’m just not sure it has control software.
I know Repetier, pronterface, and matter control all work.
Crazy to think I haven’t tried, I guess I always print from an SD…sorry, kind of blows my mind.